Simona Zompi
PhD from Université Pierre et Marie Curie (2004), MD from Université René Descartes (2001), HIV Advisor at Médecins du Monde-France (2007-2008), Post-doctoral Researcher at UC Berkeley School of Public Health since 2009.
| Headline: | Scientist |
| Industries: | Biotech, Education, Health |
| Skills: | English, French, Italian, Languages, Portuguese, Spanish, Writing |
| Next step: | Start a Clinical Research organization to set up clinical trials in developing countries. Non-profit section devoted to higher education and development of Science in developing countries. |
| Interested in: | Consulting opportunities, Finding cofounders, Finding team mates, Learning about entrepreneurship, Meeting new people, Offering Expertise, Professional opportunities, Starting a company |
| Schools: | Université Pierre et Marie Curie (Paris VI), Université René Descartes (Paris V) |
WORK EXPERIENCE
| Employer: | UC Berkeley School of Public Health – Pr. Eva Harris’ lab |
| Position: | Post-doctoral Researcher |
| Time period: | January 2009 - Present |
| Description: | Tasks: Management and coordination of a research project. Identification of relevant scientific areas of research linked with the main objectives of the host laboratory. Setting up National and International collaborations as needed. Implementation and follow-up of the Research project. Writing of NIH grant proposals (R01 and U19). Writing of abstracts and articles. Presentation of research findings at International meetings. Supervision of undergraduated students and research assistants.
Expertise: Use mouse model of dengue virus infection and disease to investigate aspects of immune protection and enhancement as well as collaborating with the field site in Nicaragua to study aspects of human immune response to dengue virus infection. Skills: Project planning and implementation. Immunology and Molecular Biology – Mouse models – PCR, real-time PCR, Flow cytometry, Cell culture, B cell assays. Communication and networking Achievements: Set up new assays in the lab (multicolor flow cytometry, Elispot). Oral communication at the American Society of Tropical Medicine and Hygiene in the USA (November 2009). |
| Employer: | Médecins du Monde-France |
| Position: | HIV Advisor |
| Time period: | November 2007 - December 2008 |
| Description: | Tasks: Technical support to international HIV programs in Africa (Liberia, Benin, Zimbabwe, Tanzania, DRC, Morocco) and Asia (Myanmar, Cambodia, Viet Nam). Support for grant writing and programming (logical framework). Monitoring and evlauation of the programs (from HQ and during field visits). Training of coordinators and field staff members on programming and HIV. Expertise on HIV in humanitarian settings (member of the IASC Task Force in Geneva). Link with policy advocacy department on Human resources scarcity in the field.
Expertise: Programming, Monitoring and Evaluation. HIV prevention and treatment. Harm Reduction component. Skills: Advising on Clinical and laboratory activties, organizing trainings and workshops, evaluation for reorientation of the programs if needed, communication to funders and to the community to promote Médecins du Monde’s programs. Achievements: Completed an indicator’s guide for HIV; Organized an HIV Regional workshop in Benin; Organized a training on Programming, Monitoring and Evaluation in Benin and Democratic Republic of Congo; Finalized the HIV monitoring tool to transversally monitor HIV programs from the HQ. |
| Employer: | Médecins du Monde-France in Myanmar |
| Position: | Medical Advisor |
| Time period: | January 2007 - November 2007 |
| Description: | Tasks: Supervision of clinical and laboratory activities. Training of medical staff (30+). Update treatment protocols. Develop and implement operational research. Supervise data collection at clinical sites and analyse data in collaboration with Medical Coordinator. Advise for implementing new activties.
Expertise: HIV prevention and treatment. Harm Reduction component. Skills: Advising on Clinical and laboratory activties (CD4 count, TB diagnosis, STI diagnosis, malaria diagnosis) , organizing trainings and workshops, managing field staff, reporting and data analysis. Achievements: Improved quality of care and data collection in the clinics. Implemented HAART program in Kachin state for drug users. Conducted capacity builduing activities for 30+ clinical staff. Drafted two projects and identified possible funders for operationnal research which could be implemented in the near future in the field. |
| Employer: | Hubrecht Laboratorium – Pr H. Clevers’ lab |
| Position: | Post-doctoral Fellow |
| Time period: | January 2005 - December 2006 |
| Description: | Tasks: Management and coordination of a fundamental research project. Identification of relevant scientific areas of research linked with the main objectives of the host laboratory. Setting up National and International collaborations as needed. Implementation and follow-up of the Research project. Writing of fellowship and grant proposals. Writing of abstracts and articles. Presentation of research findings at International meetings. Supervision of undergraduated students.
Expertise: Role of the Wnt pathway in defining the gut stem cell niche. Implications in normal development of the intestine and tumor transformation. Skills: Project planning and implementation. Molecular Biology – PCR, real-time PCR, microarrays and transgenic mouse models. Communication and networking Achievements: Identified a gene responsible for Wnt pathway activation after irradiation (OACT-1). Designed the construct for a transgenic mouse model (dominant negative OACT-1). Set up a protocol for isolation of intestinal crypts suitable for FACS analysis. Poster communication at the Keystone Symposia in the USA (April 2006). |
| Employer: | Institut Pasteur – Dr J. Di Santo’s lab |
| Position: | Immunology Researcher |
| Time period: | January 2002 - December 2004 |
| Description: | Tasks: Responsible for implementation and follow-up of a fundamental research project. Supervision of Research assistants.
Expertise: Transduction signaling in murine Natural killer cells. Skills: Immunology, mouse models, cell culture, cytotoxic assays, FACS. Achievements: Identified differential pathways of NK cell response upon response to tumors, infections and bone marrow grafts both in vitro and in vivo. The results of this research have been published in high-ranked journals (among which Nature Immunology accompanied by an editorial). This work has also been presented in oral and poster presentations in International scientific meetings (European Network of Immunology Institutes in Les Embiez, France; International NK cell meeting in Nordwijk, the Netherlands; Keystone Symposia in the USA). The resulting work and research composed a PhD Thesis entitled “Anatomy of a murder – Dissecting signal transduction pathways upon activation of murine Natural killer cells”. |
| Employer: | Institut Cochin de Génétique Moléculaire – Pr S. Gisselbrecht’s lab |
| Position: | Master student |
| Time period: | January 1999 - December 2000 |
| Description: | Tasks: Conducted research in the field of hematology using human cell lines.
Skills: Biochemestry, cell culture, transfections. Achievements: Dissected the role of two proteins in signal transduction upon erythropoietin activation. Part of the results have been published in collaboration with the rest of the team in a hig-ranked journal (Blood). The resulting work and research composed a MSc dissertation entitled “Role of Gab1 and Gab2 proteins in signal transduction upon erythropoietin activation”. |
| Employer: | Assistance Publique – Hôpitaux de Paris |
| Position: | Internships |
| Time period: | January 1996 - December 2001 |
| Description: | Tasks: Internships in clinical wards. Rotation in Immunology and Hematology wards, Pneumology, Hepatology, Intensive care Unit and routine Hematology laboratory. Writing of abstracts and articles. Supervision and training of medical students.
Expertise: Acquired (HIV/AIDS) and non-acquired (SCID, Ig deficiencies…) immunodeficiencies, Hematological disorders (leukemias and lymphomas), Infectious diseases (mainly hepatitis B, C and lung infections). Skills: Diagnosis and management of immunodeficiencies in adults and pediatric cases. Diagnosis of Hematological diseases (cytology and PCR). Training of medical students. Critical and analytical skills in reading published data. Oral and written communication skills. Training. Achievements: Set up a clinical research study to improve diagnosis of pulmonary lymphomas. Results have been published in a high-ranked journal (Blood). The resulting work and research composed a MD thesis entitled “Clonality analysis of alveolar B lymphocytes contributes to the diagnostic strategy in clinical suspicion of pulmonary lymphoma”. |
| Employer: | London School of Tropical Medicine – Pr E. Riley’s lab |
| Position: | Field visit |
| Time period: | December 2006 |
| Description: |
Tasks: Evaluate laboratory capicities for implementing research project in the field. Expertise: Human Natural killer cell response to malaria. Skills: Strategic planning, institutional networking, capacity evaluation. Achievements: Developed a strategy and action plan in the area of fundamental research in a ressource-limited setting. |
EDUCATION
| University: | Université Pierre et Marie Curie (Paris VI) |
| Time period: | 2002 - 2004 |
| Degree: | Biochemestry and Immunology, PhD |
| University: | Université René Descartes (Paris V) |
| Time period: | 1990 - 2001 |
| Degree: | Specialization in Hematology, MD |
| University: | Université René Descartes (Paris V) |
| Time period: | 1999 - 2000 |
| Degree: | Dissertation, MSc |
PUBLICATIONS
| Articles: | (2009)Williams KL, Zompi S, Beatty PR. Harris E. A mouse model for studying dengue virus pathogenesis and immune response.
(2006)Caraux A, Kim N, Bell SE, Zompi S, Ranson T, Lesjean-Pottier S, Garcia-Ojeda ME, Turner M, Colucci F. Phospholipase C-gamma2 is essential for NK cell cytotoxicity and innate immunity to malignant and virally infected cells. (2004)Zompi S, Gu H and Colucci F. The absence of the Grb2-associated binder 2 (Gab2) does not perturb NK cell development and functions. (2003)Zompi S, Hamerman JA, Ogasawara K, Schweighoffer E, Tybulewicz VLJ, Di Santo JP, Lanier LL, Colucci F. NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.Highlighted in “News and Views” by Trinchieri G. The choices of a natural killer. (2001)Bouscary D, Lecoq-Lafon C, Chrétien S, Zompi S, Fichelson S, Muller O, Porteu F, Dusanter I, Gisselbrecht S, Mayeux P, Lacombe C. Mechanism of activation and role of Gab protein in erythropoietin (Epo)-induced signalling. (2004)Zompi S, Couderc LJ, Cadranel J, Antoine M, Epardeau B, Santoli F, Farcet JP, Delfau-Larue MH. Clonality analysis of alveolar B lymphocytes contributes to the diagnostic strategy in clinical suspicion of pulmonay lymphoma.Legrand O, Zompi S, Perrot JY, Faussat AM, Benderra Z, Chaoui D, Marie JP. P-glycoprotein and multidrug resistance associated protein-1 activity in 132 acute myeloid leukemias according to FAB subtyped and cytogenetic risk groups. (2001)Zompi S, Delfau MH, Stern M, Blanche P, Lahet C, Farcet JP, Couderc LJ. Lymphoid interstitial pneumonitis in HIV infected patients: usefulness of alveolar lymphocytes gene rearrangement analysis by polymerase chain reaction. (2000)Zompi S, Legrand O, Bouscary D, Blanc CM, Picard F, Casadevall N, Dreyfus F, Marie JP, Viguié F. Therapy-related acute myeloid leukaemia following successful therapy for acute promyelocytic leukaemia with t(15;17): a report of two cases and review of the literature. Zompi S, Tulliez M, Conti F, Leblond V, Gaulard P, Blanche P, Durand F, Damaj G, Dreyfus F, Louvel A, Calmus Y, Bouscary D. Rituximab for the treatement of patients with clonal lymphoproliferative disorders following orthotopic liver transplantation: a report of three cases. (1999)Bouscary D, Jondeau K, Viguie F, Zompi S, Fontenay-Roupie M, Quarre MC, Vassilief D, Dreyfus F, Casadevall N. Aplastic anemia responsive to cyclosporine complicating the evolution of polycythemia vera Breban M, Dougados M, Picard F, Zompi S, Marolleau JP, Bocaccio C, Heshmati F, Meziere M, Dreyfus F, Bouscary D. High dose cyclophosphamide and granulocyte colony stimulating factor administration for hematopoietic stem cell mobilization in refractory rheumatoid arthritis. (1997)Zompi S, Bocquet H, Houhou S. Syndrome de choc toxique d’origine médicamenteuse chez un patient séropositif pour le VIH. (2005)Zompi S, Colucci F. Anatomy of a murder - signal transduction pathways leading to activation of natural killer cells. (2002)Zompi S and Viguié F. Therapy-related acute myeloid leukaemia after successful therapy for acute promyelocytic leukaemia with t(15;17). |
INFORMATION
| Awards: | European Network of Immunology Institutes (ENII)
Young scientist travel award(2003) Alliance Egide Grant for research collaboration in Europe Collaboration with Babraham Institute, Cambridge, UK(2003-04) 'Human Frontier Science Program Fellowship for post-doctoral research(2006) Marie Curie Intra-European fellowship Fellowship for post-doctoral research(2005) Ligue Nationale Contre le Cancer Fellowship – for PhD research(2002-04) Assistance Publique-Hôpitaux de Paris Fellowship – for MSc(1999-2000) |
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Li Han Chan
BA in Economics and History, Stanford University. BSc Ski Business and Resort, Sierra Nevada College.
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