Shahriar Yaghoubi

Employer:	Stanford University
Position:	Research Scientist
Time period:	January 2007 - Present
Description:	Department of Radiology, MIPS & Bio-X Program

Employer:	Stanford University School of Medicine
Position:	Research Experience
Time period:	March 2006 - Present
Description:	Department of Radiodiology, Molecular Imaging and Bio-X Programs UCLA Medical Center, Nuclear Medicine Principal Investigator: Dr. Sanjiv S. Gambhir Project: [18F]FHBG clinical trials in patients Role: Study Director

Employer:	Stanford University School of Medicine
Position:	Research Experience
Time period:	June 2005 - Present
Description:	Department of Radiology Bio-X and Molecular Imaging Programs Department of Medicine, Division of Clinical Immunology Principal Investigators: Dr. Sanjiv S. Gambhir and Dr. Robert Negrin Project: Optimizing incorporation of imaging reporter genes into human Cytokine Induced Killer (CIK) cells Training: Lentivirus production and handling, AMAXA Nucleofection, immunology of human CIK cells and FACS analysis.

Employer:	Stanford University School of Medicine
Position:	Research Experience
Time period:	December 2004 - Present
Description:	Department of Radiology Bio-X and Molecular Imaging Programs Department of Medicine, Division of Clinical Immunology Principal Investigators: Dr. Sanjiv S. Gambhir, Dr. C. Garrison Fathman and Dr. Edgar G. Engleman Project: Evaluating the efficacy and effect of lentivirus transduction and nucleofection of imaging reporter genes into human Dendritic cells Training: Lentivirus production and handling, AMAXA Nucleofection, immunology of human Dendritic cells and FACS analysis.

Employer:	Stanford University School of Medicine
Position:	Research Experience
Time period:	July 2003 - Present
Description:	Department of Radiology Bio-X and Molecular Imaging Programs Department of Medicine, Division of Clinical Immunology & Rheumatology PIs: Dr. C. Garrison Fathman and Dr. Sanjiv Sam Gambhir Project: Imaging trafficking of adoptively transferred immune cells in vivo designed for cellular gene therapy of autoimmune diseases using optical and nuclear imaging methods. Training: Optical Imaging, FACS, Immunology of T cells and Dendritic cells, transgenic mice models for rheumatoid arthritis and diabetes.

Employer:	Stanford University
Position:	Research Associate
Time period:	July 2005 - December 2006
Description:	Department of Radiology, MIPS & Bio-X Program Department of Medicine, Immunology and Rheumatology and Center for Clinical Immunology at Stanford

Employer:	University of California, Los Angeles
Position:	Research Experience
Time period:	February 2003 - June 2003
Description:	Department of Molecular and Medical Pharmacology Crump Institute for Molecular imaging PIs: Dr. Jorge Barrio and Dr. Sanjiv Sam Gambhir Project: Evaluation of the LD50 of HSV1-tk and HSV1-sr39tk PET probes. Training: In vitro cytotoxicity MTT assay.

Employer:	University of California, Los Angeles
Position:	Research Experience
Time period:	January 2003 - February 2005
Description:	Department of Molecular and Medical Pharmacology Crump Institute for Molecular imaging Sponsor: Dr. Sanjiv Sam Gambhir Project: Evaluation of the safety of the HSV1-sr39tk PET Reporter Probe, [18F]FHBG, in preparation for an FDA IND. Training: GLP Pre-clinical Pharmaceutical Safety Assessment

Employer:	University of California, Los Angeles
Position:	Research Experience
Time period:	October 2000 - December 2002
Description:	Department of Molecular and Medical Pharmacology Crump Institute for Molecular imaging Advisor: Dr. Sanjiv Sam Gambhir Project: Linking the Expression of the p53 Therapeutic Gene to the Expression of a PET Reporter Gene (PRG) and Evaluating the Utility of PRG Imaging for Predicting the Outcome of p53 Gene Therapy. Training: Molecular Cloning; p53 Protein Detection; Recombinant Adenovirus Construction; Cancer Gene Therapy; Imaging Animals with MicroPET; Quantitative Analysis of MicroPET Image Data.

Employer:	University of California, Los Angeles
Position:	Research Experience
Time period:	January 2000 - December 2004
Description:	Department of Molecular and Medical Pharmacology Crump Institute for Molecular Imaging Advisor: Dr. Sanjiv Sam Gambhir Project: Monitoring Suicide Gene Therapy of Tumors with the Herpes Simplex Virus 1 Thymidine Kinase/Ganciclovir Regimen, Using MicroPET Imaging Training: Gene Therapy; Imaging Animals with MicroPET; Quantitative Analysis of MicroPET Image Data

Employer:	University of California, Los Angeles
Position:	Research Experience
Time period:	October 1999 - January 2001
Description:	Department of Molecular and Medical Pharmacology Crump Institute for Biological Imaging Advisor: Dr. Sanjiv Sam Gambhir Project: Clinical Evaluation of the pharmacokinetics, dosimetry, bio-safety and dosimetry of [18F]FHBG: A PET Reporter Probe for imaging HSV1-tk and HSV1-sr39tk PRG expression. Training: Clinical evaluation of a PET tracer, radiochemical dosimetry in humans, human PET image analysis, tracer pharmacokinetics.

Employer:	University of California, Los Angeles
Position:	Research Experience
Time period:	April 1999 - November 2000
Description:	Department of Molecular and Medical Pharmacology Crump Institute for Biological imaging Advisor: Dr. Sanjiv Sam Gambhir Project: Evaluating a Simple Method of Linking Gene Expression Using a Dual PET Reporter Gene and Adenoviral Model Training: Enzyme and Receptor Binding Assays; Imaging Animals with MicroPET; Quantitative Analysis of MicroPET Image Data.

Employer:	University of California, Los Angeles
Position:	Research Experience
Time period:	April 1997 - March 1999
Description:	Department of Molecular and Medical Pharmacology Directed Individual Research Advisor: Dr. Sanjiv Sam Gambhir Project: Imaging Gene Expression with Antisense Oligonucleotides Training: General techniques in Oligonucleotide Chemistry, Molecular Biology, Pharmacology and Nuclear Medicine

Employer:	University of California, Los Angeles
Position:	Research Experience
Time period:	September 1996 - March 1997
Description:	Department of Molecular and Medical Pharmacology Research Rotation Advisors: Dr. Heinrich R Schelbert and Dr. Johannes Czernin Project: Retrospective Analysis of Patient Care Outcome after Diagnosis Using Cardiac Positron Emission Tomography (PET) Images Training: Cardiac PET image and patient history analysis. Principals of PET image acquisition from humans.

Employer:	University of Southern California
Position:	Research Experience
Time period:	August 1995 - August 1996
Description:	Department of Neuroscience Directed Research Advisors: Dr. Michel Baudry and Dr. Wael Musleh General Project: Pharmacology of Long Term Potentiation Training: Preparation of acute and cultured rat hippocampal slices and Electrophysiology

Employer:	Jewish Federation Earthquake Relief Hotline
Position:	Volunteer
Time period:	November 1994 - January 1995

Employer:	University of Southern California
Position:	Research Experience
Time period:	September 1994 - December 1994
Description:	Department of Gerontology (Neuroscience Division) Directed Research (technical training) Advisor: Dr. Julie Andersen Training: Production of transgenic mice

Employer:	Harbor UCLA Research Center
Position:	Research Experience
Time period:	June 1994 - August 1994
Description:	Department of Cardiology American Heart Association Summer Internship Advisor: Dr. Robert Detrano Project: Comparing an Off-line System for the Quantitative Assessment of Coronary Calcification from Electron Beam Computerized Tomography (EBCT) Data with the Conventional Online system. Training: Interpretation of EBCT cardiac images; Statistical analysis; brief overview of different instruments to diagnose cardiac disease. Presentation of results to the American Heart Association.

Employer:	Century City Hospital
Position:	Volunteer
Time period:	June 1993 - August 1993
Description:	Department of Biomedical Engineering Services Patient Nursing Station

Employer:	University of Southern California
Position:	Research Experience
Time period:	January 1993 - May 1993
Description:	Division of Archaeology Advisor: Dr. William Fulco Project: Obtaining information on archived ancient Middle Eastern artifacts. Training: Archaeology research

University:	Stanford University
Time period:	2003 - 2005
Degree:	RSNA Postdoctoral Fellow

University:	University of California System - Los Angeles
Time period:	2003 - 2003
Degree:	Postdoctoral Fellow

University:	University of California System - Los Angeles
Time period:	1996 - 2002
Degree:	Molecular and Medical Pharmacology, PhD

University:	University of Southern California
Time period:	1992 - 1996
Degree:	Biomedical Engineering , BSc

Articles:

- Creusot RJ, Yaghoubi SS, Kodama K, Dang DN, Dang VH, Breckpot K, Thielmans K, Gambhir SS, Fathman CG. “Tissue-targeted Therapy of Autoimmune Diabetes Using Dendritic Cells Transduced to Express IL-4 in NOD Mice.” Clinical Immunology 127(2):176-187 (2008). - Tseng JR, Kang KW, Dandekar M, Yaghoubi S, Lee JH, Christensen JG, Muir S, Vincent PW, Michaud NR, Gambhir SS. “Preclinical Efficacy of the c-Met Inhibitor CE-355621 in a U87 MG Mouse Xenograft Model Evaluated by 18F-FDG Small-Animal PET.” J Nucl Med 49(1):129-134 (2008). - Yaghoubi SS, Creusot RJ, Ray P, Fathman CG, Gambhir SS. “Multimodality Imaging of T Cell Hybridoma Trafficking in Collagen Induced Arthritic Mice: Image Based Estimation of the Number of Cells Accumulating in the Mouse Paws.” Journal of Biomedical Optics 12(6): 064025_1-11 (2007). - Yaghoubi SS, Couto MA, Chen C, Polavaram L, Cui G, Sen L, Gambhir SS. “Pre-Clinical Safety Evaluation of 18F-FHBG: A PET Reporter Probe for Imaging Herpes Simplex Virus Type 1 Thymidine Kinase (HSV1-tk) or Mutant HSV1-sr39tk’s Expression.” The Journal of Nuclear Medicine 47(4): 706-715 (2006). - Penuelas I, Haberkorn U, Yaghoubi S, Gambhir SS. “Gene therapy imaging in patients for oncological applications.” European Journal of Nuclear Medicine and Molecular Imaging 32(14):S384-S403 (2005). - Yaghoubi SS, Barrio JR, Namavari M, Satyamurthy N, Phelps ME, Herschman HR, Gambhir SS. “Imaging progress of herpes simplex virus type 1 thymidine kinase suicide gene therapy in living subjects with positron emission tomography.” Cancer Gene Therapy 12:329-339 (2005). - Herschman HR, Barrio JR, Satyamurthy N, Liang Q, MacLaren DC, Yaghoubi S, Toyokuni T, Cherry SR, Phelps ME, Gambhir SS. “Monitoring Gene Therapy by Positron Emission Tomography.” Vector Targeting for Therapeutic Gene Delivery Edited by David T. Curiel and Joanne T. Douglas. Wiley-Liss, Inc. (2002). - Sun X, Annala AJ, Yaghoubi SS, Barrio JR, Nguyen KN, Toyokuni T, Satyamurthy N, Namavari M, Phelps ME, Herschman HR, Gambhir SS. “Quantitative Imaging of Gene Induction in Living Animals.” Gene Therapy 8: 1572-1579 (2001). - Yaghoubi S, Wu L, Liang Q, Toyokuni T, Barrio JR, Namavari M, Satyamurthy N, Phelps ME, Herschman HR, Gambhir SS. “Direct Correlation Between Positron Emission Tomographic Images of Two Reporter Genes Delivered by Two Distinct Adenoviral Vectors.” Gene Therapy 8: 1072-1080 (2001). - Yaghoubi S, Barrio JR, Dahlbom M, Iyer M, Namavari M, Satyamurthy N, Goldman R, Herschman HR, Phelps ME, Gambhir SS. “Human Pharmacokinetic and Dosimetry Studies of [18F]FHBG, A Reporter Probe for Imaging Herpes Simplex Virus Thymidine Kinase (HSV1-tk) Reporter Gene Expression.” Journal of Nuclear Medicine 42(8):1225-1234 (2001). - Auerbach MA, Schoder H, Hoh C, Gambhir SS, Yaghoubi S, Sayre JW, Silverman D, Phelps ME, Schelbert HR, Czernin J. “Prevalence of Myocardial Viability as Detected by Positron Emission Tomography in Patients With Ischemic Cardiomyopathy.” Circulation. 99:2921-2926 (1999).

Books:

- Shahriar S Yaghoubi and Sanjiv Sam Gambhir. “Imaging and Cancer.” In: MendelSohn, Howley, Israel, Gray and Thompson (eds.) The Molecular Basis of Cancer, 3rd ed. Philadelphia:Saunders Elsevier, Chapter 23: p309 (2008). - Abhijit De, Shahriar S Yaghoubi, and Sanjiv Sam Gambhir. “Applications of Lentiviral Vectors in Noninvasive Molecular Imaging.” In: Le Doux JM (eds.) Gene Therapy Protocols Volume 1: Production and In Vivo Applications of Gene Transfer Vectors, 3rd Edition. Totowa NJ: Humana Press, Chapter 11: p177 (2008).

Awards:

July 1, 2003 - June 30, 2005 RSNA Postdoctoral Fellowship in Basic Radiological Sciences February 2002 AAAS Honorary Mention of Scientific Poster 2001/2002 UCLA Dissertation Fellowship 2000/2001 Graduate Division Award October 2000 Pharmacology Retreat Poster Award September 2000 Pharmacology Travel Award June 2000 Crump Institute for Molecular Imaging Researcher of the month. 1996-1997 Registration fee grant. University Fellowship 1995/1996 Langston Scholarship 1995 Lifetime Membership in Golden Key National Honor Society 1993-95 Engineering Honors Colloquium 1992-95 University of Southern California, School of Engineering. Five semesters in the Dean's list 1994/1995 Gregory Scholarship 1992 Beverly Hills High School Alumni Scholarship