Reece Hart
PhD biophysics, MS CS from Washington University; Postdoctoral fellow at IBM's T.J. Watson labs; 8 years target discovery and managing research computing at Genentech; now Chief Scientist of the Genome Commons at UC Berkeley.
| Headline: | Scientist |
| Work status: | Employed Full-Time |
| Industries: | Biotech, Computing |
| Skills: | Business, C/C++, Computer Engineering, Engineering, Entrepreneurship, Leadership, Management, Perl, Software Engineering, Writing |
| Next step: | enable personally-relevant and clinically-relevant interpretations of human genomic data |
| Interested in: | Advising startups, Brainstorming, Consulting opportunities, Finding business partners, Finding cofounders, Finding team mates, Giving back, Learning about entrepreneurship, Meeting new people, Mentoring, Offering Expertise, Patenting my idea, Professional opportunities, Providing services to startups, Raising money, Starting a company |
| Schools: | University of California System - San Diego, Washington University, Saint Louis |
FULL BIO
Curriculum vitae: http://harts.net/reece/cv.pdf
Genome Commons: http://genomecommons.org/
WORK EXPERIENCE
| Employer: | The Genome Commons |
| Position: | Chief Scientist |
| Time period: | September 2009 - Present |
| Description: | Responsible for architecture, engineering, and project management of an ambitious
effort to build a shared repository of human variation and associated phenotypes, tool infrastructure, and scientific methods that facilitate genome-wide annotation. |
| Employer: | Genentech,Inc, |
| Position: | Scientist, Bioinformatics and Protein Engineering (joint appointment) Scientific Manager, Research Computing & Informatics |
| Time period: | June 2001 - September 2009 |
| Description: | Designed and implemented Unison (unison-db.org), a comprehensive protein
database that is the basis for feature-based target discovery and protein variant comparisons; also managed Research's computing strategy, budget and operations. |
| Employer: | IBM T.J. Watson Research Center |
| Position: | Postdoctoral fellow |
| Time period: | February 1999 - April 2001 |
| Description: | Refined methods for the automated discovery of protein sequence patterns and
demonstrated their use in functional classification, anonymous sequence annotation, fold-family prediction, and protein structure prediction. Left to join Genentech |
| Employer: | Salk Institute for Biological Studies |
| Position: | Research Assistant |
| Time period: | June 1988 - June 1991 |
| Description: | Assisted with the isolation a polymorphic marker on, and mapped portions of, human
chromosome 11.Advisor: Glen A. Evans, M.D., Ph.D |
EDUCATION
| University: | Washington University, Saint Louis |
| Time period: | 1991 - 1998 |
| Degree: | Molecular Biophysics, PhD |
| University: | Washington University, Saint Louis |
| Time period: | 1991 - 1994 |
| Degree: | Computer Science, MSc |
| University: | University of California System - San Diego |
| Time period: | 1986 - 1990 |
| Degree: | Molecular Biology, BA |
PUBLICATIONS
| Papers: | Unison: An Integrated Platform for Computational Biology Discovery
Hart RK, Mukhyala K. Pac Symp Biocomput. (2009). PDF Functional characterization of the Bcl-2 gene family in the zebrafish. Kratz E, Eimon PM, Mukhyala K, Stern H, Zha J, Strasser A, Hart R, Ashkenazi A. Cell Death Differ. 13(10):1631-40 (2006). PubMed PDF Computational identification and Experimental Validation of Novel Zebrafish Bcl2 Family Members Mukhyala K, Kratz E, Ashkenazi A, Hart RK unpublished manuscript (2005). PDF supplementary data Systematic and Fully Automatic Discovery of Protein Sequence Patterns Hart RK, Stolovitzky G, Royyuru AK, and Califano A J Comput Biol. 7(3-4):585-600 (2000). PubMed PDF WWW Exploring the Similarities Between Potential Smoothing and Simulated Annealing. Hart RK, Pappu RV, and Ponder JW J. Comput. Chem. 21(7):531-52 (2000). Abstract PDF Analysis and Application of Potential Energy Smoothing for Global Optimization Pappu RV, Hart RK, and Ponder JW J. Phys. Chem. B 102:9725-9742 (1998). Abstract PDF Isolation, localization, and physical mapping of a highly polymorphic locus on human chromosome 11q13. Eubanks JH, Selleri L, Hart R, Rosette C, Evans GA Genomics 11(3):720-9 (1991 Nov) PubMed |
| Patents: | WO/2007/131133 - METHODS AND COMPOSITIONS RELATING TO ZPA POLYPEPTIDES |
INFORMATION
| Clubs: | Current or past memberships: International Society for Computational Biology, AAAS, Protein
Society, Biophysical Society |
| Awards: | ● Genentech Joint Appointment in Protein Engineering (2002-current)
● Carl and Gerty Cori Graduate Student Fellowship (1995-1996) ● National Library of Medicine grant (LM07049; 1991-1994) ● NIH Training Grant (1994-1998) |
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Riley Genomics
Crescendo Bioscience is developing a broad range of quantitative, objective diagnostic tools to provide Rheumatologists with deeper clinical insights to more effectively manage patients with autoimmune and inflammatory diseases
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Pathway Genomics
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Complete Genomics
Complete Genomics high quality, affordable DNA sequencing enables commercial-scale research of the genetic mechanisms underlying drug responses and complex diseases